Домашня сторінка
→
Хімічні та біологічні науки
→
Відділення біохімії, фізіології та молекулярної біології
→
Biopolymers and Cell
→
Вiopolymers and Cell, 2017, vol. 33
→
Перегляд Вiopolymers and Cell, 2017, vol. 33 за назвою

Перегляд Вiopolymers and Cell, 2017, vol. 33 за назвою

Результати 1-20 з 40

Наступна сторінка

Aberrant DNA glycosylase-initiated repair pathway of free radicals in-duced DNA damage: implications for age-related diseases and natural aging

Matkarimov, B.T.; Saparbaev, M.K. (Вiopolymers and Cell, 2017)

Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring ...
Amazing MSC – phenomenology, problems, solutions and opportunities

Kordium, V.A.; Irodov, D.M. (Вiopolymers and Cell, 2017)

The review briefly describes the history of prediction and discovery of mesenchymal stem cells (MSCs). The evolution of our views on the nature, functions, and status of MSCs in the organism is presented. We propose that ...
Analysis of mutations in GBA gene in Ukrainian patients with Gaucher disease

Olkhovych, N.V.; Nedoboy, A.M.; Pichkur, N.O.; Gorovenko, N.H. (Вiopolymers and Cell, 2017)

Gaucher disease (MIM 230800) is the most common storage disorder, caused by hereditary deficiency of the lysosomal enzyme of glucocerebrosidase (EC 3.2.1.45). Human glucocerebrosidase gene (GBA) is mapped to the 1q21 locus, ...
Antineoplastic activity of novel thiazole derivatives

Finiuk, N.S.; Hreniuh, V.P.; Ostapiuk, Yu.V.; Matiychuk, V.S.; Frolov, D.A.; Obushak, M.D.; Stoika, R.S.; Babsky, A.M. (Вiopolymers and Cell, 2017)

The development of novel efficient substances for anticancer chemotherapy is an important problem of medicinal chemistry. Aim. To evaluate the level of cytotoxic action of novel thiazole derivatives towards tumor cell lines ...
Association of genetic polymorphism with the mutation status of the BRCA1/2 genes in spontanous breast cancer

Polinyk, S.I.; Rybchenko, L.A.; Klymenko, S.V.; Zaharceva, L.M.; Klimuk, B.T. (Вiopolymers and Cell, 2017)

Aim. To study ssociation of the FGFR2 and TOX3/LOC643714 genetic polymorphisms with the BRCA1/2 mutation status in Ukrainian female breast cancer patients without ionizing radiation impact in their histories. Methods. ...
Cardiospecific knockout of αE-catenin leads to violation of the neonatal cardiomyocytes maturation via β-catenin and Yap signaling

Balatskyi, V.V.; Ruban, T.P.; Macewicz, L.L.; Piven, O.O. (Вiopolymers and Cell, 2017)

Aim. To study the αE-catenin gene function in neonatal cardiomyocytes proliferation and matura-tion. Methods. Conditional knockout approach, histological (H&E and acridine orange staining) and molecular genetics (qPCR) ...
Chromosomal aberrations in spontaneously aborted products of conception from Ukraine

Tkach, I.R.; Huleyuk, N.L.; Zastavna, D.V.; Weise, A.; Liehr, T.; Ciszkowicz, E.; Tyrka, M. (Вiopolymers and Cell, 2017)

Aim. To investigate peculiarities of numerical chromosomal imbalances in spontaneous products of conception from Western region of Ukraine. Methods. GTG-banding, interphase mFISH with probe panels for chromosomes 13/21, ...
Chronic diseases in the context of fundamental biology

Kordium, V.A. (Вiopolymers and Cell, 2017)

The problem of chronic diseases is analyzed from the perspective of general biology. We develop and substantiate the idea that the chronic diseases are an evolutionary mechanism of cleansing the population and the species ...
Comparative analysis of nuclear localization signal (NLS) prediction methods

Lisitsyna, O.M.; Seplyarskiy, V.B.; Sheval, E.V. (Вiopolymers and Cell, 2017)

Aim. Comparative analysis of six state-of-the-art nuclear localization signal (NLS) prediction methods (PSORT II, NucPred, cNLSMapper, NLStradamus, NucImport and seqNLS). Methods. Each program was tested for correct ...
Creation of gene expression database on preeclampsia-affected human placenta

Lykhenko, O.; Frolova, A.O.; Obolenskaya, M.Yu. (Вiopolymers and Cell, 2017)

Publication of gene expression raw data in public repositories made it possible to reuse these data for cross-experiment integrative analysis and make new insights into biological phenomena. However, data uploaded by ...
Dependence of DNA persistence length on ionic conditions

Zarudnaya, M.I.; Potyahaylo, A.L.; Hovorun, D.M. (Вiopolymers and Cell, 2017)

DNA functioning requires both compaction for packaging into chromatin or virus particles and accessibility for looping to control gene expression. The persistence length (P), closely related to the bending rigidity of ...
Detection of prostate specific ETS fusion transcripts in cancer samples

Mevs, L.V.; Gerashchenko, G.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Vozianov, S.O.; Stakhovsky, E.A.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect ETS fusion transcripts in Ukrainian population and to analyze a possible relationship between the ETS fusion transcripts and clinical characteristics of prostate cancer. Methods. Quantitative PCR (q-PCR) was ...
Experimental and human population studies of DNA lesions in healthy individuals

Sjakste, N. (Вiopolymers and Cell, 2017)

DNA damage is a valuable biomarker in human molecular epidemiology being associated with many diseases. However, the level of DNA damage is influenced also by intrinsic features of healthy individuals: heredity, sex, age ...
Expression of epithelial-mesenchymal transition-related genes in prostate tumours

Gerashchenko, G.V.; Mankovska, O.S.; Dmitriev, A.A.; Mevs, L.V.; Rosenberg, E.E.; Pikul, M.V.; Marynychenko, M.V.; Gryzodub, O.P.; Stakhovsky, E.O.; Kashuba, V.I. (Вiopolymers and Cell, 2017)

Aim. To detect expression of EMT-related genes in prostate tumor samples and analyze a possible correlation between gene expression level and clinical characteristics of prostate cancer in different groups. Methods. ...
Familial adenomatous polyposis: age of onset and association with mutations of the APC gene in patients from West Ukraine

Lozynska, M.R.; Lozynskyy, Y.S.; Plawski, A.; Pinyazhko, R.O.; Prokopchuk, N.M.; Fedota, O.M. (Вiopolymers and Cell, 2017)

Aim. To evaluate the average age of familial adenomatous polyposis (FAP) onset in both males, females and in their relatives, carriers or not carriers of the APC gene mutations, to estimate the anticipation in successive ...
Generation of HEK-293 stable cell lines with disrupted expression of ribosomal protein S6 kinase (S6K1) isoforms using the CRISPR/Cas9 genome editing system

Zaiets, I.V.; Sivchenko, A.S.; Khoruzhenko, A.I.; Filonenko, V.V. (Вiopolymers and Cell, 2017)

Aim. To generate HEK-293 cells with disrupted expression of S6K1 isoforms: p85, p70 and p60. Methods. CRISPR/Cas9 gene editing, Western blotting, immunofluorescent analysis, RT-PCR analysis, MTT assay, scratch assay. ...
GFAP as a marker of reactive astrocytes in the mice brain following hemorrhagic stroke and HSV-I

Gumenyuk, A.V.; Rybalko, S.L.; Savosko, S.I.; Guzyk, M.M.; Tykhomyrov, A.O.; Ryzha, A.A.; Chaikovsky, Yu.B. (Вiopolymers and Cell, 2017)

Aim. To investigate reactive changes of GFAP-positive astrocytes as a marker of brain response following hemorrhagic stroke and HSV-I. Methods. The experiments were performed on 110 Balb/c mice weighing 18–20 g. The animals ...
Highly selective amperometric biosensor for uric acid determination in real samples

Zinchenko, O.A.; Shkotova, L.V.; Kulynych, T.U.; Zinkina, O.O.; Soldatkin, A.P. (Вiopolymers and Cell, 2017)

Aim. To develop an amperometric biosensor based on immobilized uricase (1.7.3.3) from Arthrobacter Globiformis and a platinum disk electrode for the detection of uric acid in biological fluids. Methods. To obtain a highly ...
Hit identification of CK2 inhibitors by virtual screening

Protopopov, M.V.; Starosyla, S.A.; Borovykov, O.V.; Sapelkin, V.N.; Bilokin, Y.V.; Bdzhola, V.G.; Yarmoluk, S.M. (Вiopolymers and Cell, 2017)

Aim. To search for new CK2 inhibitors by virtual screening. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 package and pharmacophore screening ...
Identification of rye chromosomes by flow cytogenetics

Alkhimova, O.G.; Zimina, O.V. (Вiopolymers and Cell, 2017)

The karyotype of the cultivated rye (Secale cereale) is one of the complex plant genomes whose chromosomes are difficult to discriminate because of their similar size. Aim. The purpose of this study is to reveal the ...

Результати 1-20 з 40

Наступна сторінка

Пошук

Розширений пошук

Перегляд

Вся бібліотека
Розділ

Перегляд Вiopolymers and Cell, 2017, vol. 33 за назвою

Репозиторій DSpace/Manakin

Перегляд Вiopolymers and Cell, 2017, vol. 33 за назвою

Пошук

Перегляд

Вся бібліотека

Розділ

Мій обліковий запис