Моделювання ксеногенних клітинних систем на твердих фазах з використанням пухлиноасоційованих та ембріональних антигенів і їх застосування в протипухлинній терапії

Abstract

The tumor cell surface (sarcoma 37) was modeled on a solid phase (aerosil) with xenogene antigens of embryonal liver of the early period of gestation. The antitumor action of obtained preparations were investigated in therapeutic experiments. It was established that the best survival rate was observed at the complex application of sarcoma 37 antigens and liver antigens of the early period gestation sorbed on aerosil. It was determined that the preparations on the basis of sarcoma 37 antigens and embryonal liver antigens of the early period gestation after immunization of mice activated the cytotoxic reactions of macrophage and lymphocyte cell lines.