Визначення ролі спадкових факторів та несприятливих чинників перинатального розвитку у формуванні ожиріння у дітей та підлітків

Abstract

Aims. To establish hereditary predisposition to the formation of obesity and determine prognostic criteria for its development in children and adolescents. Methods. Collection of genealogical materials was carried out according to P. Harter. Clinico-genealogical analysis was performed in 50 families of children and adolescents with obesity. The child-parent correlation was estimated as relationships of qualitative features in the related samples according to the 2x2 contingency table. A prognostic algorithm was developed to distinguish the predictive criteria for the formation of the pathology under investigation. Results. Clinico-genealogical analysis made it possible to reveal a hereditary predisposition to the main noncontiguous diseases in 98.3 % of the examined patients. Among the established prognostic parameters most informative and predicative was the hereditary burden of obesity. Conclusion. Calculation of the childparent phenotypic correlation enabled the authors to determine a total contribution (34 %) of the genetic component to pathological prevalence of chronic diseases in children with obesity. The share of the environmental component came to 66 %.