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Перегляд Вiopolymers and Cell, 2013, vol. 29 за темою "Reviews"

Репозиторій DSpace/Manakin

Перегляд Вiopolymers and Cell, 2013, vol. 29 за темою "Reviews"

Сортувати за: Порядок: Результатів:

  • 2'-5'-Oligoadenylates as a «tool» of innate immunity 
    Tkachuk, Z.Yu. (Вiopolymers and Cell, 2013)
    It is a matter of common knowledge, that «core» 2'-5'-oligoadenylates and their analogues posses broader biological activity than it can be predicted within the traditional «interferon» hypothesis. They exhibit immunomodulatory ...
  • 40 years within two epochs of two millennia 
    Kordium, V.A. (Вiopolymers and Cell, 2013)
    The article-generalization deals with the main directions being developed in the Department of Cell Regulatory Mechanisms during past 40 years from the moment of the Institute of Molecular Biology and Genetics of Academy ...
  • Biosensors. A quarter of a century of R&D experience 
    Soldatkin, A.P.; Dzyadevych, S.V.; Korpan, Y.I.; Sergeyeva, T.A.; Arkhypova, V.N.; Biloivan, O.A.; Soldatkin, O.O.; Shkotova, L.V.; Zinchenko, O.A.; Peshkova, V.M.; Saiapina, O.Y.; Marchenko, S.V.; El'skaya, A.V. (Вiopolymers and Cell, 2013)
    The paper is a review of the researches of Biomolecular Electronics Laboratory concerning the development of biosensors based on electrochemical transducers (amperometric and conductometric electrodes, potentiometric ...
  • Crosstalk between endophytes and a plant host within information-processing networks 
    Kozyrovska, N.O. (Вiopolymers and Cell, 2013)
    Plants are heavily populated by pro- and eukaryotic microorganisms and represent therefore the tremendous complexity as a biological system. This system exists as an information-processing entity with rather complex processes ...
  • Design and study of telomerase inhibitors based on G-quadruplex ligands 
    Negrutska, V.V.; Dubey, L.V.; Ilchenko, M.M.; Dubey, I.Ya. (Вiopolymers and Cell, 2013)
    In this review we have summarized the results of our recent research on telomerase inhibitors and G-quadruplex DNA ligands. A series of potential enzyme inhibitors were synthesized and studied. These compounds were based ...
  • Development of molecular oncohematology in Ukraine 
    Telegeev, G.D.; Dybkov, M.V.; Dubrovska, A.N.; Miroshnichenko, D.A.; Tyutyunnykova, A.P.; Maliuta, S.S. (Вiopolymers and Cell, 2013)
    Disruption of the genetic component of cells are mandatory element of malignant transformation. For the majority of blood neoplasias genetic disorders have been discovered, and they can be used for diagnosis and appropriate ...
  • Development of the system for gene therapy of AIDS on the basis of antisense RNAs 
    Shved, A.D.; Kukharenko, O.P. (Вiopolymers and Cell, 2013)
    Based on adeno-associated virus derived plasmid construct that are able to synthesize in cells antisense RNAs directed against key genes of HIV. Gematopoietic human cells carrying the created structure, acquired resistance ...
  • Evolution of cell populations in vitro: peculiarities, driving forces, mechanisms and consequences 
    Kunakh, V.A. (Вiopolymers and Cell, 2013)
    This review outlines the major features and distinctions of cell populations, types and directions of selection in such populations. Population-genetic basis for cell adaptation to growth conditions in vitro is elucidated; ...
  • From reverse transcription to human brain tumors 
    Dmitrenko, V.V.; Avdieiev, S.S.; Areshkov, P.O.; Balynska, O.V.; Bukreieva, T.V.; Stepanenko, A.A.; Chausovskii, T.I.; Kavsan, V.M. (Вiopolymers and Cell, 2013)
    Reverse transcriptase from avian myeloblastosis virus (AMV) was the subject of the study, from which the investigations of the Department of biosynthesis of nucleic acids were started. Production of AMV in grams quantities ...
  • Human genome mutation and rearrangement studies – the way to investigate monogenic and complex disease pathogenesis 
    Livshits, L.A.; Kravchenko, S.A.; Nechyporenko, M.V.; Pampukha, V.M.; Hryshchenko, N.V.; Livshyts, G.B.; Soloviov, O.O.; Tatarskyy, P.F.; Fesai, O.A.; Chernushyn, S.Yu.; Kucherenko, A.M.; Gulkovskyy, R.V. (Вiopolymers and Cell, 2013)
    The summarized results of 25-year studies of department of human genomics of IMBG NASU are presented. The investigations were focused on identification of molecular genetic nature of human genome coding and non-coding ...
  • ITSN protein family: regulation of diversity, role in signalling and pathology 
    Tsyba, L.O.; Dergai, M.V.; Skrypkina, I.Ya.; Nikolaienko, O.V.; Dergai, O.V.; Kropyvko, S.V.; Novokhatska, O.V.; Morderer, D.Ye.; Gryaznova, T.A.; Gubar, O.S.; Rynditch, A.V. (Вiopolymers and Cell, 2013)
    Adaptor/scaffold proteins of the intersectin (ITSN) family are important components of endocytic and signalling complexes. They coordinate trafficking events with actin cytoskeleton rearrangements and modulate the activity ...
  • MGMT expression: insights into its regulation. 1. Epigenetic factors 
    Iatsyshyna, A.P. (Вiopolymers and Cell, 2013)
    O⁶-methylguanine-DNA methyltransferase (MGMT) is the DNA repair enzyme responsible for removing of alkylation adducts from the O6-guanine in DNA. Despite MGMT prevents mutations and cell death, this enzyme can provide ...
  • MGMT expression: insights into its regulation. 2. Single nucleotide polymorphisms 
    Iatsyshyna, A.P.; Pidpala, O.V.; Lukash, L.L. (Вiopolymers and Cell, 2013)
    High intra- and interindividual variations in the expression levels of the human O6-methylguanine-DNA methyltransferase (MGMT) gene have been observed. This DNA repair enzyme can be a cause of resistance of cancer cells ...
  • Molecular genetic biotechnologies – the way to the welfare of the people and increasing of agriculture profitability 
    Potopalsky, A.I.; Bolsunova, O.I.; Zaika, L.A. (Вiopolymers and Cell, 2013)
    We have designed and offered a comprehensive approach to solving several problems in modern agriculture and human health. It is based on the original use of biotechnology. The mechanisms of alkylation of amines, nucleic ...
  • Nonchromosomal cytogenetic analysis of mammal somatic cells 
    Kovalova, O.A.; Bezdenezhnykh, N.A.; Kudryavets, Y.I. (Вiopolymers and Cell, 2013)
    The mutational events that take place in mammalian somatic cells influenced with different endogenous and exogenous factors are presented in this review. The nonchromosomal method of research allows taking into account the ...
  • Novel epigenetic markers of early epithelial tumor growth and prognosis 
    Gordiyuk, V.V.; Kondratov, A.G.; Gerashchenko, G.V.; Kashuba, V.I. (Вiopolymers and Cell, 2013)
    The present work is aimed at clarifying genetic and epigenetic alterations that occur during carcinogenesis and designing perspective sets of newly identified biomarkers. The tumors of kidney, cervix, colon, ovary, and ...
  • PI3K/mTOR/S6K signaling pathway – new players and new functional links 
    Filonenko, V.V. (Вiopolymers and Cell, 2013)
    This review summarizes experimental data related to the studies of PI3K/mTOR/S6K signaling conducted at the department of cell signaling. Analysis of novel S6Ks protein-protein interactions provided valuable information ...
  • Plant biomass increase: recent advances in genetic engineering 
    Sakhno, L.O. (Вiopolymers and Cell, 2013)
    Plant biomass enhancement using transgenesis in model as well as in crop plants both under optimal and stress controlled (greenhouse or growth chamber) and field conditions is observed. It was documented that genetic ...
  • Putative mechanisms of bacterial effects on plant photosystem under stress 
    Burlak, O.P.; de Vera, J.-P.; Yatsenko, V.; Kozyrovska, N.O. (Вiopolymers and Cell, 2013)
    Bacteria are micro- and nanoorganisms that spatially colonize the plant organism and comprise various types of interactions with the host ranging from pathogenic to mutualistic and symbiotic. The presence of these exo- and ...
  • Rational design of protein kinase inhibitors 
    Yarmoluk, S.M.; Nyporko, A.Yu.; Bdzhola, V.G. (Вiopolymers and Cell, 2013)
    Modern methodological approaches to rational design of low molecular weight compounds with specific activity in relation to predetermined biomolecular targets are considered by example of development of high effective ...

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