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Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles

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dc.contributor.author Gerashchenko, T.S.
dc.contributor.author Denisov, E.V.
dc.contributor.author Novikov, N.M.
dc.contributor.author Tashireva, L.A.
dc.contributor.author Kaigorodova, E.V.
dc.contributor.author Savelieva, O.E.
dc.contributor.author Zavyalova, M.V.
dc.contributor.author Cherdyntseva, N.V.
dc.contributor.author Perelmuter, V.M.
dc.date.accessioned 2019-01-25T15:43:11Z
dc.date.available 2019-01-25T15:43:11Z
dc.date.issued 2018
dc.identifier.citation Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T.S. Gerashchenko, E.V. Denisov, N.M. Novikov, L.A. Tashireva, E.V. Kaigorodova, O.E. Savelieva, M.V. Zavyalova, N.V. Cherdyntseva, V.M. Perelmuter // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 228–234. — Бібліогр.: 37 назв. — англ. uk_UA
dc.identifier.issn 1812-9269
dc.identifier.uri http://dspace.nbuv.gov.ua/handle/123456789/145631
dc.description.abstract Aim: To identify gene expression profiles involved in drug resistance of different morphological structures (tubular, alveolar, solid, trabecular, and discrete) presented in breast cancer. Material and Methods: Ten patients with luminal breast cancer have been included. A laser microdissection-assisted microarrays and qRT-PCR were used to perform whole-transcriptome profiling of different morphological structures, to select differentially expressed drug response genes, and to validate their expression. Results: We found 27 differentially expressed genes (p < 0.05) encoding drug uptake (SLC1A3, SLC23A2, etc.) and efflux (ABCC1, ABCG1, etc.) transporters, drug targets (TOP2A, TYMS, and Tubb3), and proteins that are involved in drug detoxification (NAT1 and ALDH1B1), cell cycle progression (CCND1, AKT1, etc.), apoptosis (CASP3, TXN2, etc.), and DNA repair (BRCA1 and USP11). Each type of structures showed an individual gene expression profile related to resistance and sensitivity to anticancer drugs. However, most of the genes (19/27; p < 0.05) were expressed in alveolar structures. Functional enrichment analysis showed that drug resistance is significantly associated with alveolar structures. Other structures demonstrated the similar number (10–13 out of 27) of expressed genes; however, the spectrum of resistance and sensitivity to different anticancer drugs varied. Conclusion: Different morphological structures of breast cancer show individual expression of drug resistance genes. Key Words: breast cancer, tumor heterogeneity, gene expression, chemotherapy, drug resistance. uk_UA
dc.description.sponsorship The study was supported by the Russian Science Foundation (grant # 14-15-00318). uk_UA
dc.language.iso en uk_UA
dc.publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України uk_UA
dc.relation.ispartof Experimental Oncology
dc.subject Reviews uk_UA
dc.title Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles uk_UA
dc.type Article uk_UA
dc.status published earlier uk_UA


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