Наукова електронна бібліотека
періодичних видань НАН України
періодичних видань НАН України
Translation control in apoptosis
Репозиторій DSpace/Manakin
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Translation control in apoptosis
Тема:
Reviews
Посилання:
Translation control in apoptosis / U. Liwak, M.D. Faye, M. Holcik // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 218-230. — Бібліогр.: 123 назв. — англ.
Підтримка:
The work in the author’s laboratory is supported
by operating grants from the Canadian Institutes
of Health Research (CIHR; MOP 89737 and FRN74740)
to M.H., an Ontario Graduate Scholarship to U.L. and
the Vanier Canada Graduate Scholarship to M.D.F. M.H.
is the CHEO Volunteer Association Endowed Scholar.
The authors have no competing financial interests in relation
to the work described in this manuscript.
Дата:
2012
Переглядів:
650
Завантажень:
288
Анотація:
Regulation of protein synthesis, although known for many decades, has only recently begun to be recognized as a critical control mechanism for the maintenance of cellular homeostasis and cellular stress response. One of the key advantages of translational control is the ability of cells to rapidly reprogram the protein output in response to internal or external triggers. This is particularly important during cellular response to stress that may lead to apoptosis by providing cells with a fine tuning mechanism that tips the balance between cell survival or apoptosis. In the following review we highlight several distinct mechanisms of translation control and provide specific examples of translational control during apoptosis. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
