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періодичних видань НАН України
The intersection between DNA damage response and cell death pathways
Репозиторій DSpace/Manakin
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The intersection between DNA damage response and cell death pathways
Тема:
Reviews
Посилання:
The intersection between DNA damage response and cell death pathways / S. Howsheen, E.S. Yang // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 243-254. — Бібліогр.: 128 назв. — англ.
Підтримка:
Some of the work described in this review was
supported by the IMPACT Award from the Department
of Radiation Oncology, University of Alabama-Birmingham
Comprehensive Cancer Center, a translational
scholar award from the Sidney Kimmel Foundation
for cancer research, a pilot award from the Center
for Clinical and Translational Science (CCTS) and the
Council of Center Directors (COCD) Translational Research
Intramural Pilot Grant Program (grant number
5UL1 RR025777-04) from the NIH National Center
for Research Resources, and a medical research
award from the Gabrielle’s Angel Foundation (to ESY).
We recognize that we were unable to cover all aspects
of DNA damage response and cell death pathways
in this review. We apologize to those whom we have
been unable to cite owing to space constraints.
Дата:
2012
Переглядів:
670
Завантажень:
333
Анотація:
Apoptosis is a finely regulated process that serves to determine the fate of cells in response to various stresses. One such stress is DNA damage, which not only can signal repair processes but is also intimately involved in regulating cell fate. In this review we examine the relationship between the DNA damage/repair response in cell survival and apoptosis following insults to the DNA. Elucidating these pathways and the crosstalk between them is of great importance, as they eventually contribute to the etiology of human disease such as cancer and may play key roles in determining therapeutic response. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”.
