http://dspace.nbuv.gov.ua:80/handle/123456789/161354 Mon, 13 Apr 2026 12:43:16 GMT 2026-04-13T12:43:16Z http://dspace.nbuv.gov.ua:80/bitstream/id/533773/ http://dspace.nbuv.gov.ua:80/handle/123456789/161354 http://dspace.nbuv.gov.ua:80/handle/123456789/177652 Пол потомков как фактор пластичности фенотипов агрессивности родителей Шустикова, М.В. Aim. The variability of human aggression depend on many environment factors, some of them are in the family. The offspring gender-specific traits are one of potential factors of the parents’ phenotypic plasticity. Мethods. The members of 93 two same-sex offspring nuclear families have been studied by Buss-Durkee Hostility Inventory in Kharkіv. Results. The level of physical and indirect aggression of sons fathers, physical aggression of sons mothers are higher than in daughters parents and Ukrainian citizens. We also have defined the positive correlation between levels of physical aggression in sons parents. Conclusions. The influence of a gender-specific behavior of male sibling on the phenotypic plasticity of aggression in parents is defined. Keywords: aggression, phenotypic plasticity, nuclear families. Fri, 01 Jan 2016 00:00:00 GMT http://dspace.nbuv.gov.ua:80/handle/123456789/177652 2016-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/177650 Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом Федота, А.М.; Рощенюк, Л.В.; Горайчук, И.В.; Тыжненко, Т.В.; Адмакина, А.В. Aim. Analysis of single nucleotide polymorphisms C677T, A1298C and A66G of MTHFR and MTRR one-carbon metabolism genes in patients with various forms of psoriasis in Ukrainian population. Methods. A molecular genetic analysis of 77 patients with vulgaris and arthropathic psoriasis by PCR-RFLP was carried out. Results. In patients with vulgaris and arthropathic psoriasis analysis of the distribution of frequencies of genotypes showed a statistically significant difference between them for A66G and C677T polymorphic variants. In patients with psoriasis analysis of genotype distribution of series in the two genes as a whole, showed a statistically significant difference between the theoretically expected and actual frequencies for single nucleotide polymorphisms A1298T and A66G of MTHFR and MTRR genes. Conclusions. Among patients with arthropatic psoriasis, which is the most severe form of psoriasis, the homozygotes for the wild-type allele A of A66G of MTRR gene are more common, homozygotes of the TT of C667T of MTHFR gene are found more rarely than among psoriasis vulgaris patients, which may indicate the contribution of other genes to the development of arthropatic psoriasis. Keywords: psoriasis, arthropatic psoriasis, folate cycle, MTHFR gene, MTRR gene. Fri, 01 Jan 2016 00:00:00 GMT http://dspace.nbuv.gov.ua:80/handle/123456789/177650 2016-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/177647 Генетичний аналіз поліморфізму Val89Leu гена SRD5α2 та гена SRY у пацієнтів з порушенням диференціації статі Тиркус, М.Я.; Макух, Г.В.; Тенета, М.М.; Шуварська, В.І.; Заставна, Д.В. Aim. 5α-reductase is an enzyme that converts testosterone to 5α-dihydrotestosterone (DHT) in peripheral tissues. Deficiency of the enzyme 5α-reductase causes a disturbance of the formation of the external genitalia before birth. The polymorphism Val89Leu of SRD5α2 gene is associated with decreased activity of the enzyme 5-alpha-reductase-2. Methods. DNA from probands blood samples was isolated using a modified salting out method. Microdeletions of Y‑chromosome AZF regionand SRY gene were analyzed using two multiplex PCR. The PCR products were digested with the restriction enzyme Rsa I and analyzed by electrophoresis in a 2% agarose gel. Results. In 20 newborn children with violation of sex differentiation was set male and found no genetic disorders in region of AZF Y-chromosome. Among men in the our study group homozygous genotype LeuLeu (CC) polymorphic loci Val89Leu of SRD5α2 gene was found in 45%, which is associated with a deficiency of 5-alpha-reductase. Conclusions. The results of the study polymorphic loci Val89Leu of 5-alpha-reductase-2 gene in patients with violation of sex differentiation showed that homozygous genotype LeuLeu (CC) polymorphic loci Val89Leu be a probable genetic differentiation factors violation sex. Keywords: Y-chromosome, polymorphism, sex determination, SRD5α2 gene. Fri, 01 Jan 2016 00:00:00 GMT http://dspace.nbuv.gov.ua:80/handle/123456789/177647 2016-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/177645 От генетики человека до генной терапии – эволюция понятий и терминов, знаний и практик Пискун, Р.П.; Савицкая, Е.А.; Лилевская, А.А.; Климчук, И.Н. Aim. Genetics is developing so rapidly that not only the general public, but also experts do not have time to keep an eye on changes of our ideas of the fundamental basis of life and heredity. Methods. Research, evolutionary-historical and bibliographical methods have been used. Results. It became clear that the functional processes in a cell are incredibly complex. They become extremely difficult in the whole multicellular organism. In these processes involved many of variable components that interact with each other, and form a multidimentional spatiotemporal network. Therefore, the final effect can not be deduced by mechanical addition of components. Therefore some concepts and terms have been introduced to concretize the volume of knowledge and practical use of them in a particular field of genetics – the science of heredity and variation of all living organisms. Conclusions. For the last decades genetics and molecular biology have accumulated a huge volume of information, which requires not just understanding but also review of concepts, on which the principles of understanding organization of living systems are based. Keywords: human genetics, medical genetics, clinical genetics, cytogenetics, gene therapy. Fri, 01 Jan 2016 00:00:00 GMT http://dspace.nbuv.gov.ua:80/handle/123456789/177645 2016-01-01T00:00:00Z