Experimental Oncology, 2016, № 3

The III Swedish-Ukrainian meeting on cancer diseases

Fri, 01 Jan 2016 00:00:00 GMT

The III Swedish-Ukrainian meeting on cancer diseases

The effect of ω-fatty acids on mrna expression level of PPARγ in patients with gastric adenocarcinoma

Fri, 01 Jan 2016 00:00:00 GMT

The effect of ω-fatty acids on mrna expression level of PPARγ in patients with gastric adenocarcinoma Hosseinzadeh, A.; Somi, M.-H.; Dolatkhah, H.; Esfahani, A.; Kafil, H.S.; Ardebili, S.M.M. Background: The antineoplastic role of peroxisome proliferator-activated receptor gamma (PPARγ) ligandshas previously been demonstrated in several gastric cancer cell lines. Activation of PPARγ by polyunsaturated fatty acids (PUFAs) inhibits growth and proliferationof tumor cells. In this double-blind clinical study, we evaluate the effect of PUFAs on PPARγ mRNA expression in patients with gastric adenocarcinoma. Materials and Methods: A total of 34 chemotherapy-naive patients diagnosed with gastric adenocarcinoma were enrolled in the present study. According to treatment strategies, all subjects were divided into two groups, the first group (17 individuals) received cisplatin without supplements and the second group (17 individuals) received cisplatin plus orally administered PUFAs supplements for 3 weeks. The gastric biopsy samples were obtained from all participants before and after treatment, and PPARγ mRNA expression levels were evaluated by quantitative real-time polymerase chain reaction using validated reference genes. Results: Our findings revealed that PPARγ mRNA expression is significantly upregulated in group II afterreceiving cisplatin plus orally administered PUFAs supplements for three weeks (p < 0.0001), whereas PPARγ mRNA expression did not show significant alteration in group I after receiving cisplatin alone. Conclusion: The results of the study evidence that PPARγ may act as a potential target for the therapy of human gastric adenocarcinoma.

The use of proteomic technologies in breast cancer research

Fri, 01 Jan 2016 00:00:00 GMT

The use of proteomic technologies in breast cancer research Mazur, M.G.; Pyatchanina, T.V. The main findings in the field of breast cancer proteomic research as well as modern strategies, technologies and methods of validation are reviewed. A special attention is focused on validated proteomic biomarkers of breast cancer. The data on proteomic profiling of stroma, tumor microenvironment, involvement of proteins in tumor progression, invasion and metastasis, and mechanisms of action of new generation drugs, are analyzed. The results of proteomic analysis are of high clinical importance and significantly improve tumor molecular profiling, stratification of patients, screening, diagnostics, and therapy of breast cancer.

Accessory spleen hypertrophy mimicking colon cancer metastasis

Fri, 01 Jan 2016 00:00:00 GMT

Accessory spleen hypertrophy mimicking colon cancer metastasis Ates, I.; Yazici, O.; Yazilitas, D.; Ozdemir, N.; Zengin, N. Accessory spleen is a congenital form of an ectopic splenic tissue. In this report, we present a case of a patient who was followed with the diagnosis of rectal and sigmoid colon cancer and an accessory spleen hypertrophy, which was thought to be colon cancer metastasis in the left hypochondriac region. After colectomy and splenectomy, accessory spleen that mimics cancer metastasis was diffrentially diagnosed using scintigraphy.