http://dspace.nbuv.gov.ua:80/handle/123456789/2904 2026-04-22T22:54:24Z http://dspace.nbuv.gov.ua:80/handle/123456789/3556 Прооксидантно-антиоксидантний баланс у печінці щурів після холодової ішемії в присутності 2,4-динітрофенолу та наступної реперфузії Черкашина, Д.В.; Ткачова, О.М.; Сомов, О.Ю.; Лебединський, О.С.; Семенченко, О.А.; Грищенко, В.І.; Петренко, О.Ю. The influence of the presence of an oxidative phosphorylation uncoupler 2,4-dinitrophenol (DNP) in a storage solution on the pro-oxidant/antioxidant balance in rat liver after 18-h cold ischemia and the following normothermic reperfusion is investigated. The presence of DNP on the cold ischemia stage led to the partial mitochondrial uncoupling, which was confirmed by suppression of lipid peroxidation intensity with prevention of antioxidant enzyme activity decrease (catalase, GSH-peroxidase, GSH-reductase). After the DNP removal during the following normothermic reperfusion, the gradual recovery of oxidative phosphorylation coupling occurs. This fact results in the improvement of the pro-oxidant/antioxidant liver state: a low level of TBA-active products and a high activity of catalase, GSH-peroxidase, and G6PDH are preserved. Thus, the supplementation of a storage solution with DNP seems to be the perspective approach to the prevention of isolated liver ischemia-reperfusion injury. 2007-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/3547 Нелінійна динаміка емісії крові хворих на пухлини трофобласта Орел, В.Е.; Ціп, Н.П.; Воробйова, Л.І.; Дзятковська, Н.М.; Романов, А.В.; Мельник, Ю. Г. For the profound understanding of the etiology of uterine choriocarcinoma, a study of peculiarities of the non-linear dynamics of blood emission in patients with trophoblastic tumors is undertaken. In patients with hydatidiform mole with spontaneous remission, the spread parameter of phase diagrams of blood emission differs from that in patients with postmolar trophoblastic tumors and choriocarcinoma. For spontaneous chemiluminescence of blood serum, it was, respectively, by 21 and 6 % lower, whereas it was, respectively, by 21 and 25 % higher for the mechanoemission of whole blood. Relatively healthy women had the index of blood mechanoemission by 42 % lower than patients with hydatidiform mole with spontaneous remission. In pragmatic aspect, the above peculiarities can be used for the diagnostics and prognosis of the course of trophoblastic tumors and to promote a better understanding of mechanisms of pathogenesis of choriocarcinoma. 2007-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/3299 Оригiнальний пiдхiд до синтезу арилсульфонiлзамiщених аналогiв ациклонуклеозидiв Сливчук, С.Р.; Броварець, В.С.; Драч, Б.С. A original approach to the synthesis of acyclonucleosides containing arylsulfonyl groups in position 5 of the uracil fragment has been developed. 2007-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/3292 Реакцiя органiв та тканин iмунної системи кролiв на рiзнi режими iмунiзацiї BCG Швець, Ю.В.; Шпак, Є. Г.; Скiвка, Л.М.; Позур, В.К. The effect of different modes of BCG immunization on cytomorphologic characteristics of organs and tissues of the immune system in two rabbit species (White Giant and Gray Giant) is investigated. More significant positive changes in cellularity and weight indices of lymphoid organs are observed in White Giant rabbits under the intravenous and combined (intravenous with intranasal and intramuscular with subcutaneous) immunogene administration. This can be the evidence of genetic distinctive features in the immune response to BCG antigens in different rabbit species. 2007-01-01T00:00:00Z