http://dspace.nbuv.gov.ua:80/handle/123456789/133131 2026-04-28T05:02:56Z http://dspace.nbuv.gov.ua:80/handle/123456789/139076 Antitumor and adjuvant effects of phagelysates of E.coli in mice with Ehrlich carcinoma Gambashidze, K.; Khorava, P.; Azaladze, T.; Kalandarishvili, K.; Jaiani, E.; Lasareishvil, B.; Azaladze, A.; Tediashvili, M. Aim: To augment anti-tumor host response and overcome the tumor-induced immunosuppression is of paramount importance especially when patient is subjected to radio-/chemotherapy and immune system suffers significantly. Various immunological methods have been employed as supplemental antitumor therapies. We were aimed to investigate the antitumor potential of phagelysates of gram-negative bacteria and their adjuvant effects for conventional chemotherapy in experiment. Methods: Bacterial phagelysates of E.coli and purified suspensions of corresponding Un bacteriophage were obtained by standard methods of phage research. Experiments were carried out on BL57C/6J mice bearing transplanted Ehrlich carcinoma. Different regimens of phagelysate administration (0,5 ml E. coli phagelysate, 3/8 times with 5 day intervals) and conventional chemotherapy (combination of Doxorubicin 60 mg/m2, Cyclophosphan 800 mg/m2, Ftoruracil 600 mg/m2, 3 times with 21 day intervals) were tested. Treatment efficacy was evaluated by tumor growth inhibition percent, index of malignant growth, lifespan and survival percent. Results: Experiments have shown that application of optimal doses of E. coli phagelysate can be well tolerated in mice. No stimulation or support of malignant growth was observed. E. coli phagelysate exhibited significant anticancer effect and adjuvant efficacy. Cancer development was delayed in 65% of inoculated animals in the test group. E. coli phagelysate inhibited tumor growth by 80–90% without apparent side effects. The mice survival was prolonged twice and more. On 65th-69th days of tumor growth in 13% animals complete regression of neoplasms was registered. Application of phagelysates in combination with chemotherapy significantly increased antitumor efficacy of conventional chemotherapeutic drugs. Conclusion: Application of bacterial phagelysates can be considered as promising novel strategy in cancer therapeutics. 2012-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/139073 Cancer incidence and nuclear facilities in Ukraine: a community-based stydy Bazyka, D.A.; Prysyazhnyuk, A.Ye.; Romanenko, A.Ye.; Fedorenko, Z.P.; Gudzenko, N.A.; Fuzik, M.M.; Khukhrianska, O.M.; Trotsyuk, N.K.; Gulak, L.O.; Goroch, Ye.L.; Sumkina, Ye.V. The study goal was to investigate malignant tumors incidence in 5 Ukrainian cities with nuclear hazardous enterprises: extractive, processing enterprises of uranium ore (Zhovti Wody and Dniprodzerzhynsk of Dnipropetrovsk region) and nuclear power stations (Energodar of Zaporizhska region, Pivdennoukrainsk of Mykolayivska region, Netishyn of Khmelnytska region). Materials and methods: average annual population of the cities under study in 2003–2008 was 439 600 persons. Total and specific cancer incidence was investigated. Site specific incidence was analyzed for malignancies proved to be radiosensitive in previous studies: trachea, bronchus and lung, breast, kidney, thyroid cancer and leukemia. Data on cancer cases were received in National Cancer Registry of Ukraine (National Cancer Institute). There was used the data of the State Statistics Committee of Ukraine on the size of the studied population by gender — age groups. Standardized incidence ratio of cancer at a whole and for each of five specific forms of malignancies were calculated for the population of each city and group of cities depending on the nature of industrial activity. Results: During the observed period there were registered 9 381 cancer cases in inhabitants of Ukrainian cities with radiation hazardous facilities. There was stated that cancer incidence rate in population of 5 cities significantly exceeded national and regional levels. Among specific forms of malignancy there were observed excess of lung, trachea, bronchus, breast, kidney cancer and leukemia in population of extractive, processing uranium ore cities. No excess of thyroid cancer was identified. In cities with nuclear power station there were registered excess of kidney cancer. Conclusion: Results of the study suggest the necessity to explore the role of various factors in forming the identified cancer incidence features in the Ukrainian population living near the nuclear power facilities. 2012-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/138707 "Tumor and host" by R.E. Kavetsky (1962): implications for the past, present and future Osinsky, S.P.; Kelleher, D.K.; Chekhun, V.F. 2012-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/138702 R.E. Kavetsky "Tumor and host". ‒ Kiev, 1962. ‒ 301 p. Kavetsky, R.E. 2012-01-01T00:00:00Z