http://dspace.nbuv.gov.ua:80/handle/123456789/161350 2026-04-23T22:21:27Z 2026-04-23T22:21:27Z http://dspace.nbuv.gov.ua:80/handle/123456789/177742 2021-02-16T23:26:30Z 2015-01-01T00:00:00Z

Титульні сторінки та зміст

2015-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/177551 2021-02-18T13:01:43Z 2015-01-01T00:00:00Z

Титульні сторінки та зміст

2015-01-01T00:00:00Z Чередник, Ю.О. Анопрієнко, О.В. Барбова, А.І. Журило, О.А. http://dspace.nbuv.gov.ua:80/handle/123456789/177549 2021-02-16T23:25:57Z 2015-01-01T00:00:00Z

Виявлення сучасних та предкових субліній штамів родини Beijing у київській популяції Mycobacterium tuberculosis Чередник, Ю.О.; Анопрієнко, О.В.; Барбова, А.І.; Журило, О.А. Aims Characterization of M. tuberculosis Beijing family in Kyiv’s clinical strains population by content of «modern» and «ancient» sublineages as defined by structure of NTF locus. Methods. Multiplex PCR of NTF locus, ETR-VNTR, and SNP-typing (katG463) of bacterial isolate DNA samples from Kyiv’s patients with pulmonary tuberculosis. Results. 19 clinical isolates of M. tuberculosis strains belonged to the PGG-1 by SNP-typing and to two of the most prevalent ETRVNTR Beijing genotypes (42435, 42434) showed NTF-locus structure characteristic to «modern» type. Conclusions. More samples should be analyzed to determine the proportion of «ancient» Beijing subtypes in Kyiv M. tuberculosis population. Alternative quick and convenient methods for detection of these sublineages could be considered for more effective strategy of M. tuberculosis monitoring in Kyiv. Keywords: Mycobacterium tuberculosis, molecular epidemiology, NTF-locus.

2015-01-01T00:00:00Z Поліщук, Л.В. http://dspace.nbuv.gov.ua:80/handle/123456789/177548 2021-02-16T23:25:58Z 2015-01-01T00:00:00Z

In silico пошук gvp-кластерів Streptomyces globisporus 1912-2 Поліщук, Л.В. The aims – to find of gvp-clasters in the genome of S. globisporus 1912-2. Methods. The programs BLASTN were used for in silico analysis of the S. globisporus 1912-2 contigs library. Results. Two gvp-clusters in the library of S. globisporus 1912-2 chromosome fragments were found. One gvp-cluster was localized on Contig 264, the second cluster – on Contig 756 and Contig 781. Both gvp-clusters contain 10 genes in traditional order for streptomycetes cluster: gvpO - A - F - G - Y - Z - J - L - S - K. Conclusions. In silico analysis of the primary structures of two S. globisporus 1912-2 gvp-clusters did not find significant homology in their nucleotide sequences, therefore we could suggest that they were orthologous or significant changes in their primary structures occurred as a results of mutations after duplication. Keywords: Streptomyces globisporus 1912-2, gvp-claster, homology, chromosomal DNA.

2015-01-01T00:00:00Z