http://dspace.nbuv.gov.ua:80/handle/123456789/161346 2026-04-12T00:43:26Z 2026-04-12T00:43:26Z Шеметун, Е.В. Талан, О.А. Пилинская, М.А. http://dspace.nbuv.gov.ua:80/handle/123456789/178028 2021-02-17T23:27:32Z 2013-01-01T00:00:00Z

Радиопротекторный эффект комплексного витаминного препарата «Веторон» в культуре лимфоцитов периферической крови человека Шеметун, Е.В.; Талан, О.А.; Пилинская, М.А. Aim. Investigation of the effect of complex vitamin medical product «Vetoron» on the level of chromosomal damages induced by X-ray irradiation in vitro in human peripheral blood lymphocytes. Methods. Cultivation of peripheral blood lymphocytes received from ten conditionally healthy volunteers during 48 hours; X-ray irradiation of whole blood before cultivation in a dose 1 Gy; treatment of whole blood by «Vetoron» (complex of water-soluble forms of vitamins A, E, C) in concentration 40 mkg/ml 1 hour before irradiation; G-banding staining of metaphase chromosome slides; scoring of slides under the microscope (cytogenetic analysis); identification of the full range of chromatid and chromosome aberration types. Results. The use of complex vitamin medical product «Vetoron» before X-ray irradiation of human whole blood in vitro significantly reduced radioinduced cytogenetic effect in cultured human peripheral blood lymphocytes. Conclusions. The data received indicate radioprotective effect of «Vetoron» established by cytogenetic criteria. Key words: human peripheral blood lymphocytes, in vitro irradiation, radioprotector, vitamins, chromosome aberrations.

2013-01-01T00:00:00Z Федота, А.М. Беляева, Л.В. Солодянкин, А.С. Адмакина, А.В. http://dspace.nbuv.gov.ua:80/handle/123456789/178027 2021-02-17T23:26:26Z 2013-01-01T00:00:00Z

Анализ ассоциаций полиморфных вариантов гена MTHFR с онкопатологиями у пробандов с псориазом и их родственников Федота, А.М.; Беляева, Л.В.; Солодянкин, А.С.; Адмакина, А.В. Aim. Research association of polymorphic variants of genes of folate metabolism with cancer in a ukrainian population had been investigated. Methods. Genealogical analysis of 68 probands and 440 relatives was carried out. Genomic DNA of 68 patients was analyzed by polymerase chain reaction. Results. Statistically significant higher cancer pathology burdened with native I–degree relatives of probands compared to genotypes CC–AA and TT–AA compared with population frequency. Probands with genotype CT–AC were the least burdened by native I–degree relatives with cancer pathology. Conclusion. The study of the frequency of malignant neoplasms in patients with psoriasis showed that among them persons with oncological diseases are not detected. It is known that cysteine is a powerful antioxidant, that, apparently, is one of the factors cancer protector not only for patients with psoriasis, but also for their native I–degree relatives as heterozygotes for single nucleotide polymorphisms C677T and A1298C MTHFR gene. Key words: psoriasis, cancer, hyperhomocysteinemia, methylenetetrahydrofolate reductase.

2013-01-01T00:00:00Z Федота, А.М. http://dspace.nbuv.gov.ua:80/handle/123456789/178003 2021-02-18T23:26:22Z 2013-01-01T00:00:00Z

Анализ динамики генетико-демографических параметров (численности и половозрастных характеристик населения) малых городов и сел Восточной Украины Федота, А.М. Aims. Genetic and demographic characteristics of small rural and urban populations of Kharkov region had been investigated and their dynamics over the past twelve years had been analyzed. Methods. Different types of methods of human genetic (population and genetic-epidemiological study, estimating of marital structure and random inbreeding) and statistical analysis had been carried out. Results. The investigation has been conducted on some Eastern Ukraine populations for 1996 and 2008 has shown that the demographic process of small towns and villages has such characteristics as follows: the decreasing of effective numbers, the share lowering of the persons to be married and the share reducing of ones in the reproductive age. Conclusions. The data indicate that founded estimates of genetic and demographic parameters may be a cause of increasing of the level of inbreeding and frequencies of autosomal recessive disorders in Ukrainian populations. Key words: population, sex-age structure, marriage structure, genetic safety.

2013-01-01T00:00:00Z Утевская, О.М. Агджоян, А.Т. Пшеничнов, А.С. Дибирова, Х.Д. Чухряева, М.И. Атраментова, Л.А. Балановская, Е.В. Балановский, О.П. http://dspace.nbuv.gov.ua:80/handle/123456789/178002 2021-02-17T23:28:59Z 2013-01-01T00:00:00Z

Сходство украинских популяций из различных территориальных подразделений по маркерам Y-хромосомы Утевская, О.М.; Агджоян, А.Т.; Пшеничнов, А.С.; Дибирова, Х.Д.; Чухряева, М.И.; Атраментова, Л.А.; Балановская, Е.В.; Балановский, О.П. Aims. To compare the genetic diversity of the Ukrainian regions by the Y-chromosome haplogroups, which are the high effective genetic markers for similar populations. Methods. The genotyping of Y-chromosome markers. Multivariate statistical analysis, correlation analysis. Results. The spectrum and frequency of Y chromosome haplogroups in the Ukrainian populations correspond to the genetic pattern of Eastern Europe. The frequency distribution of Y-chromosome haplogroups in different Ukrainian populations are similar. The genetic similarity of Ukrainian population or difference between them is not determined by the geographical distance. Conclusions. Ukrainian population belonging to different historical and territorial associations are homogeneous for Y-chromosome markers and have a higher genetic similarity to each other than to the neighboring ethnic groups. Key words: Y-chromosome, haplogroup, Ukrainians, population, gene pool.

2013-01-01T00:00:00Z