http://dspace.nbuv.gov.ua:80/handle/123456789/133179 2026-04-06T20:03:45Z 2026-04-06T20:03:45Z Imaniar, R. Syahruddin, E. Soepandi, P.Z. Putra, A.C. Nurwidya, F. http://dspace.nbuv.gov.ua:80/handle/123456789/139256 2018-06-22T13:10:00Z 2018-01-01T00:00:00Z

Mediastinal yolk sac tumor infiltrating the heart Imaniar, R.; Syahruddin, E.; Soepandi, P.Z.; Putra, A.C.; Nurwidya, F. Background: As a rare tumor, yolk sac tumor is a type of neoplasm that appears like the yolk sac, extraembryonic mesenchyme, and allantois. The mediastinum is the second most frequent area after the gonadal area. Case report: We present an extremely rare case of 15 years old boy with mediastinal yolk sac tumor. The boy came with the chief complaint of swelling of the neck and face. Computed tomography scan of the chest revealed bulky mass with a cystic component that infiltrated the heart. The diagnosis of mediastinal yolk sac tumor was made after core needle biopsy. Histopathologic analysis revealed tumor mass with solid and microcystic structure and pleomorphic nucleus within the tumor cells. Laboratory finding showed elevated serum alpha-fetoprotein level reaching more than 8000 ng/ml. Echocardiography revealed a mass in the right atrium. The patient condition was rapidly deteriorated due to his vena cava superior syndrome. Unfortunately, the patient died two days after diagnosis and we did not have the chance to do the therapy. Conclusion: Mediastinal yolk sac tumor is a rare malignancy that requires comprehensive management. The diagnosis should be made based on histopathological findings with the addition of thoracic computer tomography scan to assess the degree of infiltration to surrounding organ. A life-threatening condition such as vena cava superior syndrome should be assessed promptly to allow for immediate treatment.

2018-01-01T00:00:00Z http://dspace.nbuv.gov.ua:80/handle/123456789/139255 2018-06-20T00:05:38Z 2018-01-01T00:00:00Z

Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv, Ukraine, May 21-24, 2018

2018-01-01T00:00:00Z Kian, R. Moradi, S. Ghorbian, S. http://dspace.nbuv.gov.ua:80/handle/123456789/139254 2018-06-20T00:06:45Z 2018-01-01T00:00:00Z

Role of components of microRNA machinery in carcinogenesis Kian, R.; Moradi, S.; Ghorbian, S. MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major factors contributing to miRNA biogenesis and has constituted basic principles of miRNA function. More recently, it was confirmed that various miRNAs are clearly implicated in human malignancies, such as lung, breast, ovarian, bladder, colon cancer and other kinds of carcinoma. In addition, dysregulation in the miRNA machinery elements such as Dicer, Drosha, DGCR8, Argonaut, and TRBP could be involved in the progress of many tumor types. The purpose of the current review was to compile growing information besides how miRNA biogenesis and gene silencing are modified to develop cancer.

2018-01-01T00:00:00Z Ben Kridis, W. Sghaier, S. Toumi, N. Boudawara, Z. Khanfir, A. Daoud, J. Frikha, M. http://dspace.nbuv.gov.ua:80/handle/123456789/139253 2018-06-20T00:11:02Z 2018-01-01T00:00:00Z

A long survival of a patient with brain metastasis of unknown site of the primary tumor Ben Kridis, W.; Sghaier, S.; Toumi, N.; Boudawara, Z.; Khanfir, A.; Daoud, J.; Frikha, M. Eighty percent of brain metastases (BM) are diagnosed in patients with known primary site of cancer. BM of unknown primary represents a difficult diagnosis. In up to 15% of patients with BM, the site of the primary tumor will not be detected despite investigations. The prognosis of this entity is very poor. We report here a case of a long survival of a patient with brain metastasis of unknown primary. The conclusion that can be drawn is that within BM of unknown primary exist patients with a very good prognosis that must be collected and published in order to base recommendations.

2018-01-01T00:00:00Z