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Understanding the mechanism of DNA threshold elongation
Репозиторій DSpace/Manakin
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Understanding the mechanism of DNA threshold elongation
Тема:
Свойства нелинейных биофизических систем со сложной внутренней структурой
Інший ID:
PACS: 87.14.gk, 87.15.La, 87.15.hp, 63.20.Pw
Посилання:
Understanding the mechanism of DNA threshold elongation / S.N. Volkov // Физика низких температур. — 2018. — Т. 44, № 7. — С. 893-904. — Бібліогр.: 64 назв. — англ.
Підтримка:
I am grateful to Arnold Markovich Kosevich for fruitful
cooperation and stimulating discussions for a number of
years. I also would like to thank Maxim Frank-Kamenetskii
for critical remarks and useful discussion of the presented
results. As well, I want to thank Richard Lavery for sending the data on conformational analysis of a stretched
DNA, and Polina Kanevska for help in making drawings
and discussion.
The present work was partially supported by the Program of Fundamental Research of the Department of Physics and Astronomy of the National Academy of Sciences of
Ukraine.
Дата:
2018
Переглядів:
373
Завантажень:
256
Анотація:
The mechanism of threshold elongation of DNA macromolecule (overstretching) is studied within the frame-work of phenomenological approach, accounting both external (stretching) and internal (conformational) dis-placement components. As shown, the overstretching of DNA under the action of an external force can occur in two stages. Firstly, due to the coupling between the components, at a some critical value of external force a conformational bistability is formed in the macromolecule structure. In turn, the appearance of bistability stimulates the formation of domains in the DNA chain with two different conformations (B and S). Secondly, under favorable boundary conditions, the conformationally induced deformation acquires the possibility to propagate along the macromolecule as domain walls. In this way the bistability occurrence in the macromolecule conformation provides a threshold effect of elongation. The calculated contributions in DNA overstretching show agreement with the observed data, and allow to explain the dependence of macromolecule threshold elongation on nucleotide content.
