Перегляд за автором "Razin, S.V."

Сортувати за: Порядок: Результатів:

  • C-methods to study 3D organization of the eukaryotic genome 
    Gavrilov, A.A.; Razin, S.V.; Iarovaia, O.V. (Вiopolymers and Cell, 2012)
    В последнее время становится все более очевидным, что пространственная организация эукариотического генома играет важную роль в регуляции экспрессии генов. Трехмерную (3D) организацию генома можно исследовать с помощью ...
  • Dynamic nature of active chromatin hubs 
    Gavrilov, A.A.; Philonenko, E.S.; Iarovaia, O.V.; Razin, S.V. (Вiopolymers and Cell, 2011)
    Aim. In order to get more information about organization of active chromatin hubs and their role in the regulation of gene transcription we have studied the spatial organization of the a-globin gene domain in cultured chicken ...
  • Folded genome as a platform for the functional compartmentalization of the eukaryotic cell nucleus 
    Ioudinkova, E.S.; Gavrilov, A.A.; Razin, S.V. (Вiopolymers and Cell, 2014)
    In a number of recent studies a tight interconnection between the spatial organization of the eukaryotic genome and its functioning has been demonstrated. Moreover, it is becoming evident that the folded DNA by itself ...
  • Insulators in vertebrates: regulatory mechanisms and chromatin structure 
    Ulianov, S.V.; Markova, E.N.; Gavrilov, A.A.; Razin, S.V. (Вiopolymers and Cell, 2012)
    Инсуляторы были открыты как геномные элементы, способные прерывать связь между промотором и энхансером (энхансер-блокирующая активность) и ограничивать распространение гетерохроматина (барьерная активность). У дрозофилы ...
  • Intranuclear localization of transcription factories and immunoglobulin heavy chain gene alleles during human B-cell maturation 
    Pichugin, A.V.; Iarovaia, O.V.; Sklyar, I.V.; Lacombe, G.; Razin, S.V.; Fest, T.; Lipinski, M.; Vassetzky, Y.S. (Вiopolymers and Cell, 2016)
    Immunoglobulin heavy chain (IGH) gene locus is expressed monoallelically in human B cells. Aim. To study the role of nuclear organization in regulation of the IGH expression during B-cell differentiation. Methods. ...
  • Lamina–associated chromatin in the context of the mammalian genome folding 
    Ulianov, S.V.; Shevelyov, Y.Y.; Razin, S.V. (Вiopolymers and Cell, 2016)
    Eukaryotic interphase chromatin is folded hierarchically. Mammalian chromosomes are partitioned into topo-logically associating domains (TADs) whose interactions with each other drive the spatial segregation of the bulk ...
  • MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix 
    Vassetzky, Y.S.; Ioudinkova, E.S.; Razin, S.V. (Вiopolymers and Cell, 2009)
    Aim. CO326 is a chicken nuclear scaffold/matrix attachment region (MAR) associated with the nuclear matrix in several types of chicken cells. It contains a binding site for a sequence-specific DNA-binding protein, F326. ...
  • Nucleosomal packaging of eukaryotic DNA and regulation of transcription 
    Golov, A.K.; Razin, S.V.; Gavrilov, A.A. (Вiopolymers and Cell, 2014)
    The eukaryotic nucleus harbors genomic DNA, which is tens of thousands of times greater in linear size than the nuclear diameter. Its high condensation is due to DNA packaging in chromatin, and DNA wrapping around nucleosomal ...
  • Stress factor – dependent differences in molecular mechanisms of premature cell senescence 
    Petrova, N.V.; Velichko, A.K.; Petrova, N.V.; Razin, S.V.; Kantidze, O.L. (Вiopolymers and Cell, 2015)
    Cell senescence is an established cell stress response in the form of a permanent proliferation arrest accompanied by a complex phenotype. Senescent cells share several crucial features, such as lack of DNA synthesis, ...
  • Treatment of lymphoid cells with the topoisomerase II poison etoposide leads to an increased juxtaposition of AML1 and ETO genes on the surface of nucleoli 
    Rubtsov, M.A.; Glukhov, S.I.; Allinne, J.; Pichugin, A.; Vassetzky, Y.S.; Razin, S.V.; Iarovaia, O.V. (Вiopolymers and Cell, 2011)
    AML1 and ETO genes are known partners in the t(8,21) translocation associated with the treatment-related leukaemias in the patients receiving chemotherapy with DNA-topoisomerase II (topo II) poisons. Aim. To determine ...